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(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate

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  1. -4-Hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP, HMBPP) or -4-hydroxy-dimethylallyl pyrophosphate (HDMAPP) is an intermediate of the non-mevalonate pathway of isoprenoid biosynthesis

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on February 6, 2009
  2. The enzyme HMB-PP synthase (GcpE, IspG) catalyzes the conversion of 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate (MEcPP) into HMB-PP, and HMB-PP is then converted further to isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) by

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on February 6, 2009
  3. an essential metabolite in most pathogenic bacteria including Mycobacterium tuberculosis as well as in malaria parasites, but is absent from the human host

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on February 6, 2009
  4. the physiological activator ("phosphoantigen") for human Vγ9/Vδ2 T cells, the major γδ T cell population in peripheral blood

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on February 6, 2009
  5. With a bioactivity of 0.1 nM it is 10,000-10,000,000 more potent than any other natural compound, such as IPP or alkyl amines

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on February 6, 2009
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