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Addiction module

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  1. Addiction modules are toxin-antitoxin systems

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on February 11, 2009
  2. Each consists of a pair of genes that specify two components: a stable toxin and an unstable antitoxin that interferes with the lethal action of the toxin

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on February 11, 2009
  3. Found first in E. coli on low copy number plasmids, addiction modules are responsible for a process called the postsegregational killing effect

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on February 11, 2009
  4. When bacteria lose these plasmid(s) (or other extrachromosomal elements), the cured cells are selectively killed because the unstable antitoxin is degraded faster than the more stable toxin

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on February 11, 2009
  5. The term "addiction" is used because the cell depends on the de novo synthesis of the antitoxin for cell survival

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on February 11, 2009
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