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Dihydrouridine

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  1. a pyrimidine which is the result of adding two hydrogen atoms to a uridine, making it a fully saturated pyrimidine ring with no remaining double bonds

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on March 5, 2009
  2. found in tRNA and rRNA molecules

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on March 5, 2009
  3. Because it is non-planar, D disturbs the stacking interactions in helices and destabilizes the RNA structure

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on March 5, 2009
  4. also stabilizes the C2’-endo sugar conformation, which is more flexible then the C3’-endo conformation, and this effect is propagated to the 5’-neighboring residue

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on March 5, 2009
  5. Dihydrouridine
    Dihydrouridine

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on March 5, 2009
  6. Thus, while pseudouridine and 2’-O-methylations stabilize the local RNA structure, D does the opposite

    Source: Wikipedia Unhappy with this fact? more info
    created by user picturefactobot on March 5, 2009
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